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White Paper Overview in Functional Genomics and Proteomics

The PFGRC supports "White Papers" in the areas of Gene Expression studies, Comparative Genomics, Gene Knock Outs, Proteomics and Bioinformatics as well as associated methodologies and technologies. It is our desire to continue to identify the most relevant resources and collaborative opportunities between the scientific community and our Center.

The PFGRC will make its resources, technology platforms, and scientific and technical expertise available for functional genomics and proteomics studies for the purpose of developing genomic/proteomic data sets of broad interest and value to the scientific community. To this end, the "White Paper" concept is designed to provide outreach to the scientific community such that investigators can propose collaborative projects that are responsive to the greater resource and research needs of the infectious disease and biodefense communities utilizing the extensive resources and expertise provided by the PFGRC.

The capabilities of the PFGRC with respect to reagents and resources are described in significant detail on the PFGRC web site. The PFGRC and NIAID Program Staff will give priority to proposals in the following areas:

  1. Gene Expression Studies – the PFGRC has reagents and expertise in the application of 70-mer based glass slide DNA microarrays for studying the pathogenicity of infectious agents,
  2. Comparative Genomics – areas of interest include novel gene discovery, multi-strain comparisons through comparative genomic hybridization, and polymorphism analysis utilizing Affymetrix GeneChip technology,
  3. Proteomics – the PFGRC has significant expertise in comparative protein profiling through a variety of protein separation and mass spectrometry techniques and platforms, high throughput platforms for protein purification and expression, and the production and application of protein arrays,
  4. Bioinformatics – the PFGRC Bioinformatics staff develops and supports software applications for gene expression, comparative genomics, and proteomic analyses.

In developing a "White Paper" proposal the investigator(s) should be particularly cognizant of the relevance of the proposed study to the greater infectious disease and biodefense communities as a whole (see criteria for submitting requests).