The NIAID sponsored Pathogen Functional Genomics Resource Center (PFGRC) (NIAID contract N01-AI-15447) has funded two studies investigating the proteome of vancomycin intermediate resistant Staphylococcus aureus (VISA). Emerging clinical VISA isolates are also methicillin-resistant and cause increasing public health concerns, because few antibiotics remain to treat life-threatening infections with these bacterial pathogens. Data, including interactive 2DE gel images and mass spectrometry protein identifications from the first study, profiling cell envelope-associated proteins, is available here. Similar data from the second study, comparing protein abundance among isogenic strains that differ in resistance to vancomycin, is available here.